Effect of isoniazid on the dehydrogenase activity of Mycobacterium tuberculosis.

Evaluating the effect of Dracocephalum kotschyi methanol extract on Mycobacterium tuberculosis

Background and objectives: Tuberculosis (TB) is the major public health problem in the world. Each year there are 2-3 million deaths worldwide caused by TB. The increasing incidence of Multi Drug Resistance tuberculosis (MDR-TB) worldwide highlights the urgent need to search for new anti-tuberculosis compounds. It has been reported that medicinal plant, Dracocephalum kotschyi, possesse...

Virulence in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from south India

Isoniazid, is the only antituberculous drug for which the relation between lack of virulence and acquisition of resistance was associated. INH-resistant mutants were shown to contain defective katG gene. Classical studies showed that INH-resistant south Indian isolates have lower virulence in guinea pigs and higher susceptibility to H2O2. It is of interest to assess the virulence in south India...

Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates

Isoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran

Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...

IMPORTANCE OF CATALASE ENZYME IN VIRULENCE OF ISONIAZID RESISTANT ST RAINS OF MYCOBACTERIUM TUBERCULOSIS IN GUINEAPIGS

In this study, twenty-five strains of Mycobacterium tuberculosis resistant to isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ]. The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains resistant to INH as well as virulent to guinea-pigs, eight of them wer...